Dissolution is defined as which process?

Dissolution is defined as which process?

• A. Breakdown of oral drug into smaller particles
• B. Movement from the GI tract into bloodstream
• C. Process of combining small drug particles with liquid to form a solution
• D. Metabolism of drug in liver

Answer: (B)

Dissolution is the step where a solid drug dissolves in a liquid to form a solution. In the GI tract, this means the solid dosage form releases its drug into the surrounding fluids so the drug becomes dissolved and can then diffuse toward the intestinal lining. This dissolution step is essential because only dissolved molecules can be absorbed through the gut lining into the bloodstream. The rate of dissolution depends on solubility, surface area (smaller particles provide more surface area), agitation, pH, and temperature. It’s related to, but distinct from, disintegration (breaking the tablet into smaller pieces) and absorption (movement of the dissolved drug from the GI tract into the bloodstream). Metabolism in the liver is a separate process that can occur after absorption.

Dissolution is the step where a solid drug dissolves in a liquid to form a solution. In the GI tract, this means the solid dosage form releases its drug into the surrounding fluids so the drug becomes dissolved and can then diffuse toward the intestinal lining. This dissolution step is essential because only dissolved molecules can be absorbed through the gut lining into the bloodstream. The rate of dissolution depends on solubility, surface area (smaller particles provide more surface area), agitation, pH, and temperature. It’s related to, but distinct from, disintegration (breaking the tablet into smaller pieces) and absorption (movement of the dissolved drug from the GI tract into the bloodstream). Metabolism in the liver is a separate process that can occur after absorption.